From Chapter 2:
A curious scene took place at Oxford in 1605 when King James visited the University. Two subjects were debated by learned dons before his Majesty, and one of them, at his own suggestion, was, "Whether the frequent use of tobacco is good for healthy men?" Among those who spoke were Doctors Ailworth, Gwyn, Gifford and Cheynell. The discussion, needless to say, being conducted in the presence of the author of the "Counterblaste to Tobacco," was not favourable to the herb. The King summed up in a speech which hopelessly begged the question while it contained plenty of strong denunciation. After his Majesty had spoken, one learned doctor, Cheynell, who is described by the recorder, Isaac Wake, the Public Orator of the University, as second to none of the doctors, had the courage to rise and, with a pipe held forth in his hand, to speak both wittily and eloquently in favour of tobacco from the medicinal point of view, praising it to the skies, says Wake, as of virtue beyond all other remedial agents. His wit pleased both the King and the whole assembly, whom it moved to laughter; but when he had finished, his Majesty made a lengthy rejoinder in which he said some curious things. He objected to the medicinal use of tobacco, and quite agreed with previous speakers that such a use must have arisen among Barbarians and Indians, who he went on to say had as much knowledge of medicine as they had of civilized customs. If, he argued, there were men whose bodies were benefited by tobacco-smoke, this did not so much redound to the credit of tobacco, as it did reflect upon the depraved condition of such men, that their bodies should have sunk to the level of those of Barbarians so as to be affected by remedies such as were effective on the bodies of Barbarians and Indians! His Majesty kindly suggested that doctors who believed in tobacco as a remedial agent should take themselves and their medicine of pollution off to join the Indians.

From Chapter 8:
Coleridge, in the "Biographia Literaria," gives an amusing account of his own experience of an attempt to smoke in company with a party of tradesmen. In 1795 he was travelling about the country endeavouring to secure subscriptions to the periodical publication he had started called The Watchman. At Birmingham one day he dined with a worthy tradesman, who, after dinner, importuned him "to smoke a pipe with him, and two or three other illuminati of the same rank." The remainder of the moving story must be told in Coleridge's own words. "I objected," he says, "both because I was engaged to spend the evening with a minister and his friends, and because I had never smoked except once or twice in my life-time, and then it was herb tobacco mixed with Oronooko. On the assurance, however, that the tobacco was equally mild, and seeing too that it was of a yellow colour,—not forgetting the lamentable difficulty I have always experienced in saying, 'No,' and in abstaining from what the people about me were doing,—I took half a pipe, filling the lower half of the bole with salt. I was soon, however, compelled to resign it, in consequence of a giddiness and distressful feeling in my eyes, which, as I had drunk but a single glass of ale, must, I knew, have been the effect of the tobacco. Soon after, deeming myself recovered, I sallied forth to my engagement; but the walk and the fresh air brought on all the symptoms again, and I had scarcely entered the minister's drawing-room, and opened a small pacquet of letters, which he had received from Bristol for me, ere I sank back on the sofa in a sort of swoon rather than sleep. Fortunately I had found just time enough to inform him of the confused state of my feelings, and of the occasion. For here and thus I lay, my face like a wall that is white-washing, deathly pale, and with the cold drops of perspiration running down it from my forehead, while one after another there dropped in the different gentlemen, who had been invited to meet, and spend the evening with me, to the number of from fifteen to twenty. As the poison of tobacco acts but for a short time, I at length awoke from insensibility, and looked round on the party, my eyes dazzled by the candles which had been lighted in the interim. By way of relieving my embarrassment one of the gentlemen began the conversation with 'Have you seen a paper to-day, Mr. Coleridge?' 'Sir,' I replied, rubbing my eyes, 'I am far from convinced that a Christian is permitted to read either newspapers or any other works of merely political and temporary interest.' This remark, so ludicrously inapposite to, or rather, incongruous with, the purpose for which I was known to have visited Birmingham, and to assist me in which they were all met, produced an involuntary and general burst of laughter; and seldom indeed have I passed so many delightful hours as I enjoyed in that room from the moment of that laugh till an early hour the next morning."