From Chapter 1:
"Tarlton, as other gentlemen used, at the first comming up of tobacco, did take it more for fashion's sake than otherwise, and being in a roome, set between two men overcome with wine, and they never seeing the like, wondered at it, and seeing the vapour come out of Tarlton's nose, cryed out, fire, fire, and threw a cup of wine in Tarlton's face. Make no more stirre, quoth Tarlton, the fire is quenched: if the sheriffes come, it will turne to a fine, as the custome is. And drinking that againe, fie, sayes the other, what a stinke it makes; I am almost poysoned. If it offend, saies Tarlton, let every one take a little of the smell, and so the savour will quickly goe: but tobacco whiffes made them leave him to pay all."

From Chapter 5:
When excavations were in progress early in 1901, preparatory to the construction of Kingsway and Aldwych, they included the removal of bodies from the burying-grounds of St. Clement Danes and St. Mary-le-Strand; and among the bones were found a couple of the curious tobacco-pipes called "plague-pipes," because they are supposed to have been used as a protection against infection by those whose office it was to bury the dead. These pipes have been dug up from time to time in numbers so large that one antiquary, Mr. H. Syer Cuming, has ventured to infer that "almost every person who ventured from home invoked the protection of tobacco."