From Chapter 1:
"'It requires no effort of the fancy to picture these three men [Shakespeare, Bacon and Raleigh] as lounging in a window of Durham House, puffing the new Indian weed from silver bowls, discussing the highest themes in poetry and science, while gazing on the flower-beds and the river, the darting barges of dame and cavalier, and the distant pavilions of Paris garden and the Globe.'" This is a pure "effort of the fancy" so far as Bacon and Shakespeare are concerned. Shakespeare's absolute silence about tobacco forbids us to assume that he smoked; but of Raleigh the picture may be true enough. The house had, as Aubrey tells us, "a little turret that looked into and over the Thames, and had the prospect which is as pleasant perhaps as any in the world"; and it would be strange indeed if the owner of the noble house did not often smoke a contemplative pipe in the window of that pleasant turret.

From Chapter 8:
Coleridge, in the "Biographia Literaria," gives an amusing account of his own experience of an attempt to smoke in company with a party of tradesmen. In 1795 he was travelling about the country endeavouring to secure subscriptions to the periodical publication he had started called The Watchman. At Birmingham one day he dined with a worthy tradesman, who, after dinner, importuned him "to smoke a pipe with him, and two or three other illuminati of the same rank." The remainder of the moving story must be told in Coleridge's own words. "I objected," he says, "both because I was engaged to spend the evening with a minister and his friends, and because I had never smoked except once or twice in my life-time, and then it was herb tobacco mixed with Oronooko. On the assurance, however, that the tobacco was equally mild, and seeing too that it was of a yellow colour,—not forgetting the lamentable difficulty I have always experienced in saying, 'No,' and in abstaining from what the people about me were doing,—I took half a pipe, filling the lower half of the bole with salt. I was soon, however, compelled to resign it, in consequence of a giddiness and distressful feeling in my eyes, which, as I had drunk but a single glass of ale, must, I knew, have been the effect of the tobacco. Soon after, deeming myself recovered, I sallied forth to my engagement; but the walk and the fresh air brought on all the symptoms again, and I had scarcely entered the minister's drawing-room, and opened a small pacquet of letters, which he had received from Bristol for me, ere I sank back on the sofa in a sort of swoon rather than sleep. Fortunately I had found just time enough to inform him of the confused state of my feelings, and of the occasion. For here and thus I lay, my face like a wall that is white-washing, deathly pale, and with the cold drops of perspiration running down it from my forehead, while one after another there dropped in the different gentlemen, who had been invited to meet, and spend the evening with me, to the number of from fifteen to twenty. As the poison of tobacco acts but for a short time, I at length awoke from insensibility, and looked round on the party, my eyes dazzled by the candles which had been lighted in the interim. By way of relieving my embarrassment one of the gentlemen began the conversation with 'Have you seen a paper to-day, Mr. Coleridge?' 'Sir,' I replied, rubbing my eyes, 'I am far from convinced that a Christian is permitted to read either newspapers or any other works of merely political and temporary interest.' This remark, so ludicrously inapposite to, or rather, incongruous with, the purpose for which I was known to have visited Birmingham, and to assist me in which they were all met, produced an involuntary and general burst of laughter; and seldom indeed have I passed so many delightful hours as I enjoyed in that room from the moment of that laugh till an early hour the next morning."