From Chapter 1:
Who first smoked a pipe of tobacco in England? The honour is divided among several claimants. It has often been stated that Captain William Middleton or Myddelton (son of Richard Middleton, Governor of Denbigh Castle), a Captain Price and a Captain Koet were the first who smoked publicly in London, and that folk flocked from all parts to see them; and it is usually added that pipes were not then invented, so they smoked the twisted leaf, or cigars. This account first appeared in one of the volumes of Pennant's "Tour in Wales." But the late Professor Arber long ago pointed out that the remark as to the mode of smoking by cigars and not by pipes was simply Pennant's speculation. The authority for the rest of the story is a paper in the Sebright MSS., which, in an account of William Middleton, has the remark: "It is sayed, that he, with Captain Thomas Price of Plâsyollin and one Captain Koet, were the first who smoked, or (as they called it) drank tobacco publickly in London; and that the Londoners flocked from all parts to see them." No date is named, and no further particulars are available.

From Chapter 5:
The belief in the prophylactic power of tobacco was, however, very generally held. When Mr. Samuel Pepys on June 7, 1665, for the first time saw several houses marked with the ominous red cross, and the words "Lord, have mercy upon us" chalked upon the doors, he felt so ill at ease that he was obliged to buy some roll tobacco to smell and chew. There is nothing to show that Pepys even smoked, which considering his proficiency in the arts of good-fellowship, is perhaps a little surprising. Defoe, in his fictitious but graphic "Journal of the Plague Year in London," says that the sexton of one of the London parishes, who personally handled a large number of the victims, never had the distemper at all, but lived about twenty years after it, and was sexton of the parish to the time of his death. This man, according to Defoe, "never used any preservative against the infection other than holding garlic and rue in his mouth, and smoking tobacco."