From Chapter 2:
An amusing example of the bragging "tobacconist" is pictured for us in Ben Jonson's "Bobadil." Bobadil may perhaps be somewhat of an exaggerated caricature, but it is probable that the dramatist in drawing him simply exaggerated the characteristic traits of many smokers of the day. This hero, drawing tobacco from his pocket, declares that it is all that is left of seven pounds which he had bought only "yesterday was seven-night." A consumption of seven pounds of tobacco in eight days is a pretty "tall order"! Then he goes on to brag of its quality—your right Trinidado—and to assert that he had been in the Indies, where the herb grows, and where he himself and a dozen other gentlemen had for the space of one-and-twenty weeks known no other nutriment than the fume of tobacco. This again was tolerably "steep" even for this Falstaff-like braggart. He continues with more bombast in praise of the medicinal virtues of the herb—virtues which were then very firmly and widely believed in—and is replied to by Cob, the anti-tobacconist, who, with equal exaggeration on the other side, denounces tobacco, and declares that four people had died in one house from the use of it in the preceding week, and that one had "voided a bushel of soot"!

From Chapter Chapter 8:
Cowper then goes on to attack tobacco in lines which show how unpopular smoking at that date was with ladies, and which have since often been quoted by anti-tobacconists with grateful appreciation:

Pernicious weed! whose scent the fair annoys,
Unfriendly to society's chief joys,
Thy worst effect is banishing for hours
The sex whose presence civilizes ours;
Thou art indeed the drug a gardener wants,
To poison vermin that infest his plants,
But are we so to wit and beauty blind,
As to despise the glory of our kind,
And show the softest minds and fairest forms
As little mercy as the grubs and worms?

Notwithstanding this "satiric wipe," it is not likely that Cowper would have had much sympathy with John Wesley, who, in his detestation of what had been his father's solace at Epworth, forbade his preachers either to smoke or to take snuff.