From Chapter 1:
In this "Report" Hariot says of the tobacco plant: "There is an herbe which is sowed a part by itselfe and is called by the inhabitants Vppówoc: In the West Indies it hath divers names, according to the severall places and countries where it groweth and is used: The Spaniardes generally call it Tobacco. The leaves thereof being dried and brought into powder: they use to take the fume or smoke thereof by sucking it through pipes made of claie into their stomacke and heade: from whence it purgeth superfluous fleame and other grosse humors, openeth all the pores and passages of the body: by which meanes the use thereof, not only preserveth the body from obstructions: but if also any be, so that they have not beane of too long continuance, in short time breaketh them: wherby their bodies are notably preserved in health, and know not many greevous diseases wherewithall wee in England are oftentimes afflicted."

From Chapter 7:
There is no mention of Parson Trulliber's pipe, but that pig-breeder and lover can hardly have been a non-smoker. Both the other clerical characters who appear in the book, the Roman Catholic priest who makes an equivocal appearance in the eighth chapter of the third book, and Parson Barnabas, who thinks that his own sermons are at least equal to Tillotson's, smoke their pipes. The other smokers in "Joseph Andrews" are the surgeon and the exciseman who, early in the story, are found sitting in the inn kitchen with Parson Barnabas, "smoking their pipes over some syderand"—the mysterious "cup" being a mixture of cider and something spirituous—and Joseph's father, old Gaffer Andrews, who appears at the end of the story, and complains bitterly that he wants his pipe, not having had a whiff that morning.